医学检验科学科带头人、科主任，科教科副主任（主持工作）兼科技处处长，同济大学临床检验诊断学博士后，上海市“超级博士后”，江苏省“333工程”培养对象，连云港市“521人才”第一层次培养对象，连云港市“十四五”科教强医工程花果山医学重点人才、盐城市医学重点人才。

1. 社会兼职：

（1）组织兼职：兼任国家自然科学基金函评专家、中国中西医结合学会检验医学专业委员会肿瘤分子诊断专家委员会常务委员、中国老年保健协会实验医学分会常务委员、中国抗癌协会肿瘤标志物委员会CACA委员、中国内分泌性高血压协作组委员、江苏省医院协会临床检验管理专业委员会委员、江苏省医院协会医院科技教育管理专业委员会青年委员、江苏省医学会微生物与免疫学会委员、江苏省免疫学会感染与免疫学会常务委员、江苏省生物技术协会第八届常务理事、江苏省社会办医医疗机构协会检验医学专业委员会副主任委员、江苏省中西医结合学会循证医学专业委员会、连云港市医学会微生物与免疫学会主任委员、连云港市医学会科学研究分会副主任委员、连云港市医院协会科教管理专业委员会常务委员；

（2）期刊兼职：Indian Journal of Pharmaceutical Sciences执行主编、iMeta编委、BIO Integration编委、Biocell 编委、Military Medical Research科学编辑、Gastroenterology & Hepatology Research编委、Interdisciplinary Medcine（IMed）青年编委 、Metabolism and Target Organ Damage青年编委、Biomedical Engineering Communications青年编委、Intelligent Oncology青年编委、iLABMED青年编委、Journal of Translational Internal Medicine青年编委、Medicine Bulletin青年编委、Current Molecular Pharmacology青年编委、TMR青年编委、《中华临床免疫和变态反应杂志》青年编委、《临床与病理杂志》第二、三、四届中青年编委等。

2. 研究方向：

①慢性病多病共存精准分子诊断标志物的筛选与应用；

②感染微生态与免疫微环境重塑、耐药及致病机制；

③肿瘤微环境;

④AI与医工交叉在慢性疾病诊疗中的应用。

3. 主持/参与课题：

主持/参与国家自然科学基金、省部级、市级及校级科研课题13项：

[1] CPS1 作为结直肠癌肺转移标志物的潜在价值及重塑转移前微环境形成的致病机制研究，连云港市第六期“521高层次人才培养工程，LYG065212024074，202410-202610，16万，主持，在研。

[2] 基于凋亡小体ANGPTL4蛋白诱导CD8+T细胞双硫死亡探究其作为结直肠癌免疫治疗疗效预测标志物的价值，江苏省卫健委科教处重点项目，K2024084，202501-202712，40万，主持，在研。

[3] 渔业人员海分枝杆菌感染的血清学检测与流行病学调查研究，江苏省卫健委职业健康处技术类重点项目，JSZJ20241204，202409-202708，20万，主持，在研。

[4] 真菌性炎症性肠病恶性病变的机制研究，南京医科大学康达学院科研发展基金，KD2024KYJJ040，202501-202612，10万，主持，在研。

[5] 蛋白酶体20S亚基β7介导肿瘤相关巨噬细胞M2样极化促进肺腺癌恶性进展的机制研究，江苏大学医教协同重点项目，JDYY2023085，2023.6-2025.5，3万，主持，在研。

[6] 连云港市科技公共服务平台建设在中华药港建设的推进机制与人才保障问题研究，连云港市哲学社会科学界联合会，SLYZ237090，2023，1万，主持，结题。

[7] 微滴式数字PCR联合质谱技术在“假阴性”细菌阴道病鉴定中的应用，连云港市卫健委面上项目，202321，202310-202610，3万，主持，在研。

[8] 外泌体circPACRGL与NETs作为标志物组合在结直肠癌转移预测、诊断及评估中的应用研究，连云港市抗癌协会重点项目，ZD202305，20241-202612，10万，主持，在研。

[9] 肠道菌群通过Exosomal circPACRGL诱导中性粒细胞胞外陷阱促进结直肠癌发展的作用及其临床价值研究，中国博士后基金面上项目，2020M681399，202007-202212，8万，主持，结题。

[10] 肠道菌群通过外泌体诱导中性粒细胞胞外陷阱促进结直肠癌发展的作用机制及其临床价值研究，上海市人力资源社会保障局，2020409，202101-202212，20万，主持，结题。

[11] 外泌体中多种miRNA/lncRNAs联合检测在卵巢癌早期诊断中临床价值研究，国家自然科学基金青年基金，81802084，201901-202112，21万，主持，结题。

[12] 多亚型视网膜神经节细胞轴突的再生和视觉功能的修复，国家自然科学基金面上项目，81873765，201901-202212，56万，参与，结题。

[13] 建立数字PCR技术检测外泌体EGFR突变对肺癌及脑转移靶向用药指导作用，江苏省卫健委科教处指导项目，Z2019039，201701-201912，1万，主持，结题。

4. 近5年以第一/通讯（含并列）及参与作者发表论文：

[1] Miao Y, Zhao K, Shang A. Complexity of Prostate Cancer. JAMA. 2025 .

[2] Yongchang Miao, Yuanhao Wei, Anquan Shang. Revolutionizing Gastroenterology with Artificial Intelligence: Clinical Insights and Challenges. Gastroenterology. 2025 .

[3] Anquan Shang, Weiwei Wang, Kun Zhao. Artificial Intelligence in Inflammatory Bowel Disease Management. Gastroenterology. 2025 .

[4] Wang Xinyue, Shang Anquan, Chen Haowei, et al. Global, regional, and national disease burden of multidrug-resistant tuberculosis without extensive drug resistance, 1990-2021: Findings from the Global Burden of Disease Study 2021. Drug Resist Updat. 2025. 82: 101265.

[5] Z Li Q Chen, Y Zhang Z Ye, Y Song Y Zhang, C Gu J Tan, Y Yang A Shang. Osteosarcoma cells‐derived exosomal YES1 promote tumor progression via MAPK pathway. Interdisciplinary Medicine. 2025 .

[6] Wang Jun, Gu Chen-Zheng, Wang Peng-Xiang, et al. Integrative proteomic profiling of tumor and plasma extracellular vesicles identifies a diagnostic biomarker panel for colorectal cancer. Cell Rep Med. 2025. 6(5): 102090.

[7] Zhang Yiwei, Li Zihua, Lu Hengli, et al. Pan-cancer analysis uncovered the prognostic and therapeutic value of disulfidptosis. NPJ Precis Oncol. 2025. 9(1): 50.

[8] Shang An-Quan, Yan Hong, Xiang Ze, et al. Serum exosome-derived ALDH1A1 can greatly predict the prognosis of patients with hepatitis E virus-related acute liver failure. Hepatobiliary Pancreat Dis Int. 2025. 24(2): 170-176.

[9] Zan Pengfei, Zhang Yi, Zhu Yidong, et al. Therapeutic implications and comprehensive insights into cellular senescence and aging in the tumor microenvironment of sarcoma. Discov Oncol. 2025. 16(1): 50.

[10] Zhang C, Akanyibah FA, Wang X, Mao F, Shang A. The role of apoptosis and its potential as a therapeutic target in inflammatory bowel disease associated with colorectal cancer. Am J Transl Res. 2025. 17(7): 5718-5745.

[11] Wang Xiu, Peng Jianhua, Cai Peipei, et al. The emerging role of the gut microbiota and its application in inflammatory bowel disease. Biomed Pharmacother. 2024. 179: 117302.

[12] Qiao Yaru, Tang Xiaohua, Liu Ziyue, et al. Therapeutic Prospects of Mesenchymal Stem Cell and Their Derived Exosomes in the Regulation of the Gut Microbiota in Inflammatory Bowel Disease. Pharmaceuticals (Basel). 2024. 17(5): 607.

[13] Mo Yuanhang, Shang Anquan, Wei Guoguo, et al. Juvenile idiopathic arthritis and primary ovarian failure: a two-sample Mendelian randomization analysis in a mixed-gender cohort. Front Endocrinol (Lausanne). 2024. 15: 1340993.

[14] Zhao Chenyang, Shang Anquan, Wu Han, Li Qiong, Peng Lixiu, Yue Chaoyan. Causal relationship between genetically predicted uterine leiomyoma and cancer risk: a two-sample Mendelian randomization. Front Endocrinol (Lausanne). 2024. 15: 1429165.

[15] Chang Wenjing, Zhu Jichao, Yang Dianyu, et al. Plasma versican and plasma exosomal versican as potential diagnostic markers for non-small cell lung cancer. Respir Res. 2023. 24(1): 140.

[16] Ping Yili, Huang Jingjuan, Zhu Jichao, et al. Comprehensive analyses of molecular features, prognostic values, and regulatory functionalities of m(6)A-modified long non-coding RNAs in lung adenocarcinoma. Clin Epigenetics. 2023. 15(1): 60.

[17] Shu Chenggan, Wang Weiwei, Wu Lipei, et al. LINC00936/microRNA-221-3p Regulates Tumor Progression in Ovarian Cancer by Interacting with LAMA3. Recent Pat Anticancer Drug Discov. 2023. 18(1): 66-79.

[18] Gu Chenzheng, Shang Anquan, Liu Gege, et al. Identification of CD147-positive extracellular vesicles as novel non-invasive biomarkers for the diagnosis and prognosis of colorectal cancer. Clin Chim Acta. 2023. 548: 117510.

[19] Li Zihua, Duan Zhengwei, Jia Keyao, et al. A Combined Risk Score Model to Assess Prognostic Value in Patients with Soft Tissue Sarcomas. Cells. 2022. 11(24): 4077.

[20] Shen Liping, Zhang Wei, Yuan Yi, Zhu Weipei, Shang Anquan. Vaginal microecological characteristics of women in different physiological and pathological period. Front Cell Infect Microbiol. 2022. 12: 959793.

[21] Shen Liping, Wang Weiwei, Hou Weiwei, et al. The function and mechanism of action of uterine microecology in pregnancy immunity and its complications. Front Cell Infect Microbiol. 2022. 12: 1025714.

[22] Han Fei, Wang Weiwei, Shi Meng, et al. Outer membrane vesicles from bacteria: Role and potential value in the pathogenesis of chronic respiratory diseases. Front Cell Infect Microbiol. 2022. 12: 1093327.

[23] Song Shu, Tang Haicheng, Quan Wenqiang, Shang Anquan, Ling Chunhua. Estradiol initiates the immune escape of non-small cell lung cancer cells via ERβ/SIRT1/FOXO3a/PD-L1 axis. Int Immunopharmacol. 2022. 107: 108629.

[24] Zhao Shuo, Shang Anquan, Guo Mengchen, Shen Liangliang, Han Yu, Huang Xin. The advances in the regulation of immune microenvironment by Candida albicans and macrophage cross-talk. Front Microbiol. 2022. 13: 1029966.

[25] Wang Haiyang, Hu Jiayi, Wu Junlu, Ji Ping, Shang Anquan, Li Dong. The Function and Molecular Mechanism of Commensal Microbiome in Promoting Malignant Progression of Lung Cancer. Cancers (Basel). 2022. 14(21): 5394.

[26] Liu Gege, Wu Junlu, Chen Guofei, Shang Anquan. The potential therapeutic value and application prospect of engineered exosomes in human diseases. Front Cell Dev Biol. 2022. 10: 1051380.

[27] Chen Chen, Shang Anquan, Gao Yuting, et al. PTBPs: An immunomodulatory-related prognostic biomarker in pan-cancer. Front Mol Biosci. 2022. 9: 968458.

[28] Chen Chen, Shang Anquan, Sun Zujun, et al. Urinary Exosomal Long Noncoding RNA TERC as a Noninvasive Diagnostic and Prognostic Biomarker for Bladder Urothelial Carcinoma. J Immunol Res. 2022. 2022: 9038808.

[29] Gao Yuting, Zhou Hao, Liu Gege, Wu Junlu, Yuan Yi, Shang Anquan. Tumor Microenvironment: Lactic Acid Promotes Tumor Development. J Immunol Res. 2022. 2022: 3119375.

[30] Gu Chenzheng, Wu Junlu, Zhang Wei, et al. Immune Infiltration of Ulcerative Colitis and Detection of the m6A Subtype. J Immunol Res. 2022. 2022: 7280977.

[31] Tian Jiale, Wang Weiwei, Zhu Jichao, et al. Histone Methyltransferase SETDB1 Promotes Immune Evasion in Colorectal Cancer via FOSB-Mediated Downregulation of MicroRNA-22 through BATF3/PD-L1 Pathway. J Immunol Res. 2022. 2022: 4012920.

[32] Zhang Wei, Wang Weiwei, Hou Weiwei, et al. The diagnostic utility of IL-10, IL-17, and PCT in patients with sepsis infection. Front Public Health. 2022. 10: 923457.

[33] Li Zihua, Huang Hui, Wu Xinbo, et al. SRSF3 Expression Serves as a Potential Biomarker for Prognostic and Immune Response in Pan-Cancer. Front Oncol. 2022. 12: 808530.

[34] Zhang Wei, Wang Weiwei, Wu Junlu, et al. Immune cell-lipoprotein imbalance as a marker for early diagnosis of non-small cell lung cancer metastasis. Front Oncol. 2022. 12: 942964.

[35] Wu Lipei, Wang Weiwei, Tian Jiale, et al. Intravenous Delivery of RNA Encoding Anti-PD-1 Human Monoclonal Antibody for Treating Intestinal Cancer. J Cancer. 2022. 13(2): 579-588.

[36] Qiao Dan, Gu Chenzheng, Wang Weiwei, et al. Tumor-Originated Exosomal hsa-miR-3937 as a Minimally Invasive Early Biomarker for Liquid Biopsy of Colorectal Cancer. J Oncol. 2022. 2022: 6990955.

[37] Yan Wenhui, Liu Wuchao, Wu Junlu, et al. Neuropeptide Y in the amygdala contributes to neuropathic pain-like behaviors in rats via the neuropeptide Y receptor type 2/mitogen-activated protein kinase axis. Bioengineered. 2022. 13(4): 8101-8114.

[38] Gu Chenzheng, Chang Wenjing, Wu Junlu, et al. NCOA4: An Immunomodulation-Related Prognostic Biomarker in Colon Adenocarcinoma and Pan-Cancer. J Oncol. 2022. 2022: 5242437.

[39] Deng Tongyang, Shang Anquan, Zheng Ying, Zhang Lianzhen, Sun Hong, Wang Wei. Log (Lactobacillus crispatus/ Gardnerella vaginalis): a new indicator of diagnosing bacterial vaginosis. Bioengineered. 2022. 13(2): 2981-2991.

[40] Gu Chenzheng, Li Caiyun, Wang Weiwei, et al. Immune Infiltration and N(6)-Methyladenosine ncRNA Isoform Detection in Acute Lung Injury. J Oncol. 2022. 2022: 3922299.

[41] Wu Junlu, Chen Guofei, Wang Weiwei, et al. GTPBP4: A New Therapeutic Target Gene Promotes Tumor Progression in Non-Small Cell Lung Cancer via EMT. J Oncol. 2022. 2022: 2164897.

[42] Wang Weiwei, Wu Lipei, Tian Jiale, et al. Cervical Cancer Cells-Derived Extracellular Vesicles Containing microRNA-146a-5p Affect Actin Dynamics to Promote Cervical Cancer Metastasis by Activating the Hippo-YAP Signaling Pathway via WWC2. J Oncol. 2022. 2022: 4499876.

[43] Zhai Guang-Hua, Zhang Wei, Xiang Ze, et al. Diagnostic Value of sIL-2R, TNF-α and PCT for Sepsis Infection in Patients With Closed Abdominal Injury Complicated With Severe Multiple Abdominal Injuries. Front Immunol. 2021. 12: 741268.

[44] Cui Jie, Tian Jiale, Wang Weiwei, et al. IGF2BP2 promotes the progression of colorectal cancer through a YAP-dependent mechanism. Cancer Sci. 2021. 112(10): 4087-4099.

[45] Sun Zujun, Ji Shurong, Wu Junlu, et al. Proteomics-Based Identification of Candidate Exosomal Glycoprotein Biomarkers and Their Value for Diagnosing Colorectal Cancer. Front Oncol. 2021. 11: 725211.

[46] Wang Fei, Tian Jiale, Pang Li, et al. Retinoic Acid-Induced Gene G(RIG-G) as a Novel Monitoring Biomarker in Leukemia and Its Clinical Applications. Genes (Basel). 2021. 12(7): 1035.

[47] Wang Wei-Wei, Wu Lipei, Lu Wenying, et al. Lipopolysaccharides increase the risk of colorectal cancer recurrence and metastasis due to the induction of neutrophil extracellular traps after curative resection. J Cancer Res Clin Oncol. 2021. 147(9): 2609-2619.

[48] Yu Y, Wang W, Lu W, Chen W, Shang A. Inhibin β-A (INHBA) induces epithelial-mesenchymal transition and accelerates the motility of breast cancer cells by activating the TGF-β signaling pathway. Bioengineered. 2021. 12(1): 4681-4696.

[49] Wu Lipei, Wang Weiwei, Tian Jiale, et al. Engineered mRNA-expressed bispecific antibody prevent intestinal cancer via lipid nanoparticle delivery. Bioengineered. 2021. 12(2): 12383-12393.

[50] Shang Anquan, Gu Chenzheng, Wang Weiwei, et al. Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p- TGF-β1 axis. Mol Cancer. 2020. 19(1): 117.

[51] Shang Anquan, Gu Chenzheng, Zhou Chen, et al. Exosomal KRAS mutation promotes the formation of tumor-associated neutrophil extracellular traps and causes deterioration of colorectal cancer by inducing IL-8 expression. Cell Commun Signal. 2020. 18(1): 52.

[52] Cui Jie, Shang Anquan, Wang Weiwei, Chen Wei. Rational design of a GLP-1/GIP/Gcg receptor triagonist to correct hyperglycemia, obesity and diabetic nephropathy in rodent animals. Life Sci. 2020. 260: 118339.

[53] Ma J, Zhang L, Shang A, et al. LINC02163 promotes colorectal cancer progression via miR-511-3p/AKT3 axis. Artif Cells Nanomed Biotechnol. 2020. 48(1): 961-968.

[54] Pan Hongchao, Su Yunnan, Xie Yini, et al. Everestmab, a novel long-acting GLP-1/anti GLP-1R nanobody fusion protein, exerts potent anti-diabetic effects. Artif Cells Nanomed Biotechnol. 2020. 48(1): 854-866.

[55] Sun Junjun, Wang Xuan, Liu Wenfang, et al. Novel evidence for retinoic acid-induced G (Rig-G) as a tumor suppressor by activating p53 signaling pathway in lung cancer. FASEB J. 2020. 34(9): 11900-11912.

[56] Liu Wanchao, Yang Dianyu, Chen Longmei, et al. Plasma Exosomal miRNA-139-3p is a Novel Biomarker of Colorectal Cancer. J Cancer. 2020. 11(16): 4899-4906.

[57] Qi Jia, Wang Weiwei, Lu Wenying, Chen Wei, Sun Hui, Shang Anquan. Design and biological evaluation of novel BF-30 analogs for the treatment of malignant melanoma. J Cancer. 2020. 11(24): 7184-7195.

[58] Zeng Bingjie, Ji Ping, Chen Chen, et al. A nomogram from the SEER database for predicting the prognosis of patients with non-small cell lung cancer. Int J Biochem Cell Biol. 2020. 127: 105825.

[59] Wu Junlu, Wang Xuetao, Shang Anquan, et al. PLAC8 inhibits oral squamous cell carcinogenesis and epithelial-mesenchymal transition via the Wnt/β-catenin and PI3K/Akt/GSK3β signaling pathways. Oncol Lett. 2020. 20(5): 128.

5. 中国发明专利

（1）已授权

[1] 一种结直肠癌诊断标志物及其应用，李冬、商安全、孙祖俊、王旋、谷晨峥、吴军录、权文强，CN113866413B；

[2] 基于尿液外泌体的膀胱癌标志物lncRNA TERC及其应用，李冬、陈晨、孙祖俊、吴军录、商安全，CN113637753B；

[3] 肿瘤复发转移检测方法及系统，商安全、胡娟、张伟、苗永昌、赵玉胜、侯杰、王微微，CN119132494B；

[4]基于中性粒细胞极化状态的恶性肿瘤转移风险预测系统，商安全、王微微、张伟、苗永昌，CN120199495B；

（2）新申请/审中

[1]基于中性粒细胞极化特征的肿瘤免疫治疗疗效预测系统，商安全、胡娟、张伟、苗永昌、赵玉胜、侯杰、王微微，CN119479772A；

[2]一种脾脏中性粒细胞检测试剂盒及其检测方法，商安全、王微微、张伟、严文慧、秦蕊、苗永昌，国际CN202511487360.3；

[3]多通道组织来源中性粒细胞检测芯片及应用系统，商安全、王微微、张伟、严文慧、秦蕊、苗永昌，国际CN202511492193.1；

[4]一种区分人骨髓与脾脏中性粒细胞的诊断试剂盒及检测方法，商安全、王微微、张伟、严文慧、秦蕊、苗永昌，国际CH202511535234.0；

[5]基于骨髓/脾脏中性粒细胞ARG1表达的肿瘤复发风险分层试剂盒，商安全、王微微、张伟、严文慧、秦蕊、苗永昌，国际CW202511599350.9；

[6]一种基于骨髓/脾脏中性粒细胞比例的肿瘤免疫治疗疗效预测试剂盒商安全、王微微、张伟、严文慧、秦蕊、苗永昌，国际CN202511604528.4;

[7]一种肿瘤放疗康复数据监测方法和系统，董淑德、商安全、李明、侯杰、张伟、王琨，CN120853881A；

[8]基于MRI双模态自适应加权特征融合的AD特征提取方法及系统，王培军、许晓雯、商安全、沈爱军、吴晓芬、丁偕、贺浩东、张鹏龙，CN116861210A；

[9] 一种治疗骨关节炎的组合物及负载该组合物的微针贴片，李梓华、范丽敏、马骁一、商安全、陆恒立、叶展晖、任天斌、张成功， CN116617263A；

6. 国内专业著作

[1]商安全等，检验医学与临床，吉林科学技术出版社，2016.5（书/著作，第二主编）

[2]商安全等，临床医学检验指南，吉林科学技术出版社，2017.4（书/著作，第一主编）

[3]商安全等，临床分子肿瘤学，湖北科学技术出版社，2018.9（书/著作，第一主编）

[4]商安全等，临床微生物检验基础与抗感染学，2018.9（书/著作，第一主编）

[5]商安全等，炎症与肿瘤，2019. 4（书/著作，第一主编）

7. 参与执笔制定专家共识：

[1] 中国戊型肝炎研究协助组(CCSHE), 中国医师协会感染科医师分会, 国家感染性疾病临床医学研究中心. 中国戊型病毒性肝炎院内筛查管理流程专家共识(2023年版). 临床肝胆病杂志. 2023. (4): 785-794.

[2] 中国戊型肝炎研究协助组（CCSHE）, 中国医师协会感染科医师分会, 国家感染性疾病临床医学研究中心. 中国戊型病毒性肝炎院内筛查管理流程专家共识（2023年版）. 中华检验医学杂志. 2023. (6): 558-565.

[3] 中国戊型肝炎研究协助组(CCSHE), 中国医师协会感染科医师分会, 国家感染性疾病临床医学研究中心. 中国戊型病毒性肝炎院内筛查管理流程专家共识(2023年版). 中华临床感染病杂志. 2023. (2): 99-107.

[4] 中国医院协会，《临床微生物检验质量与安全管理》团体标准. 中国医院协会发布，2025.

8. 其他：

2019-2022连续四年获上海市医学会优秀青年科技工作者一等奖；2023年获淮海科学技术奖二等奖1项；2023年获连云港市医学新技术引进奖二等奖1项；2024年获淮海科学技术奖二等奖1项；2023年获连云港市医学新技术引进奖二等奖1项、三等奖2项等。