医学检验科学科带头人、科主任，科教科副主任（主持工作）兼科技处处长，同济大学临床检验诊断学博士后，上海市“超级博士后”，江苏省“333工程”培养对象，连云港市“521人才”第一层次培养对象，连云港市“十四五”科教强医工程花果山医学重点人才、盐城市医学重点人才。

1. 社会兼职：

（1）组织兼职：兼任国家自然科学基金函评专家、中国中西医结合学会检验医学专业委员会肿瘤分子诊断专家委员会常务委员、中国老年保健协会实验医学分会常务委员、中国抗癌协会肿瘤标志物委员会CACA委员、中国内分泌性高血压协作组委员、江苏省医院协会临床检验管理专业委员会委员、江苏省医院协会医院科技教育管理专业委员会青年委员、江苏省医学会微生物与免疫学会委员、江苏省免疫学会感染与免疫学会常务委员、江苏省生物技术协会第八届常务理事、江苏省社会办医医疗机构协会检验医学专业委员会副主任委员、江苏省中西医结合学会循证医学专业委员会、连云港市医学会微生物与免疫学会主任委员、连云港市医学会科学研究分会副主任委员、连云港市医院协会科教管理专业委员会常务委员；

（2）期刊兼职：Indian Journal of Pharmaceutical Sciences执行主编、iMeta编委、BIO Integration编委、Biocell 编委、Military Medical Research科学编辑、Gastroenterology & Hepatology Research编委、Interdisciplinary Medcine（IMed）青年编委 、Metabolism and Target Organ Damage青年编委、Biomedical Engineering Communications青年编委、Intelligent Oncology青年编委、iLABMED青年编委、Journal of Translational Internal Medicine青年编委、Medicine Bulletin青年编委、Current Molecular Pharmacology青年编委、TMR青年编委、《中华临床免疫和变态反应杂志》青年编委、《临床与病理杂志》第二、三、四届中青年编委等。

2. 研究方向：

①慢性病多病共存精准分子诊断标志物的筛选与应用；

②感染微生态与免疫微环境重塑、耐药及致病机制；

③肿瘤微环境;

④AI与医工交叉在慢性疾病诊疗中的应用。

3. 主持/参与课题：

   主持/参与国家自然科学基金、省部级、市级及校级科研课题13项：

[1] CPS1 作为结直肠癌肺转移标志物的潜在价值及重塑转移前微环境形成的致病机制研究，连云港市第六期“521高层次人才培养工程，LYG065212024074，202410-202610，16万，主持，在研。

[2] 基于凋亡小体ANGPTL4蛋白诱导CD8+T细胞双硫死亡探究其作为结直肠癌免疫治疗疗效预测标志物的价值，江苏省卫健委科教处重点项目，K2024084，202501-202712，40万，主持，在研。

[3] 渔业人员海分枝杆菌感染的血清学检测与流行病学调查研究，江苏省卫健委职业健康处技术类重点项目，JSZJ20241204，202409-202708，20万，主持，在研。

[4] 真菌性炎症性肠病恶性病变的机制研究，南京医科大学康达学院科研发展基金，KD2024KYJJ040，202501-202612，10万，主持，在研。

[5] 蛋白酶体20S亚基β7介导肿瘤相关巨噬细胞M2样极化促进肺腺癌恶性进展的机制研究，江苏大学医教协同重点项目，JDYY2023085，2023.6-2025.5，3万，主持，在研。

[6] 连云港市科技公共服务平台建设在中华药港建设的推进机制与人才保障问题研究，连云港市哲学社会科学界联合会，SLYZ237090，2023，1万，主持，结题。

[7] 微滴式数字PCR联合质谱技术在“假阴性”细菌阴道病鉴定中的应用，连云港市卫健委面上项目，202321，202310-202610，3万，主持，在研。

[8] 外泌体circPACRGL与NETs作为标志物组合在结直肠癌转移预测、诊断及评估中的应用研究，连云港市抗癌协会重点项目，ZD202305，20241-202612，10万，主持，在研。

[9] 肠道菌群通过Exosomal circPACRGL诱导中性粒细胞胞外陷阱促进结直肠癌发展的作用及其临床价值研究，中国博士后基金面上项目，2020M681399，202007-202212，8万，主持，结题。

[10] 肠道菌群通过外泌体诱导中性粒细胞胞外陷阱促进结直肠癌发展的作用机制及其临床价值研究，上海市人力资源社会保障局，2020409，202101-202212，20万，主持，结题。

[11] 外泌体中多种miRNA/lncRNAs联合检测在卵巢癌早期诊断中临床价值研究，国家自然科学基金青年基金，81802084，201901-202112，21万，主持，结题。

[12] 多亚型视网膜神经节细胞轴突的再生和视觉功能的修复，国家自然科学基金面上项目，81873765，201901-202212，56万，参与，结题。

[13] 建立数字PCR技术检测外泌体EGFR突变对肺癌及脑转移靶向用药指导作用，江苏省卫健委科教处指导项目，Z2019039，201701-201912，1万，主持，结题。

4. 近5年发表论文：

  【已录用论文】

[1]   Yongchang Miao, Yuanhao Wei, Anquan Shang. Revolutionizing Gastroenterology with Artificial Intelligence: Clinical Insights and Challenges. Gastroenterology. Mar 31, 2025. Accept

[2]   Anquan Shang, Weiwei Wang, Kun Zhao. Artificial Intelligence in Inflammatory Bowel Disease Management. Gastroenterology. Mar 18, 2025. Accept

【已发表论文】

[1] Y. Miao, K. Zhao, A. Shang, Complexity of Prostate Cancer, JAMA (2025).

[2] X. Wang, A. Shang, H. Chen, J. Li, Y. Jiang, L. Wang, et al., Global, Regional, and National Disease Burden of Multidrug-Resistant Tuberculosis Without Extensive Drug Resistance, 1990–2021: Findings from the Global Burden of Disease Study 2021, Drug Resist. Updat. (2025) 101265.

[3] Z. Li, Q. Chen, Y. Zhang, Z. Ye, Y. Song, Y. Zhang, et al., Osteosarcoma cells‐derived exosomal YES1 promote tumor progression via MAPK pathway, Experimental and Molecular PathologyExperimental and Molecular PathologyExperimental and Molecular Pathology (2025) e20240072.

[4] J. Wang, C.Z. Gu, P.X. Wang, J.R. Xian, H. Wang, A.Q. Shang, et al., Integrative proteomic profiling of tumor and plasma extracellular vesicles identifies a diagnostic biomarker panel for colorectal cancer, Cell Reports Medicine 6 (2025) 102090.

[5] Y. Zhang, Z. Li, H. Lu, Z. Jiang, Y. Song, Z. Ye, et al., Pan-cancer analysis uncovered the prognostic and therapeutic value of disulfidptosis, NPJ Precis Oncol 9 (2025) 50.

[6] A.Q. Shang, H. Yan, Z. Xiang, J.Q. Chen, B. Jiang, C. Jiang, et al., Serum exosome-derived ALDH1A1 can greatly predict the prognosis of patients with hepatitis E virus-related acute liver failure, HBPD INT 24 (2025) 170-176.

[7] P. Zan, Y. Zhang, Y. Zhu, Q. Chen, Z. Duan, Y. Guan, et al., Therapeutic implications and comprehensive insights into cellular senescence and aging in the tumor microenvironment of sarcoma, Horm. Cancer 16 (2025) 50.

[8] X. Wang, J. Peng, P. Cai, Y. Xia, C. Yi, A. Shang, et al., The emerging role of the gut microbiota and its application in inflammatory bowel disease, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 179 (2024) 117302.

[9] Y. Qiao, X. Tang, Z. Liu, D. Ocansey, M. Zhou, A. Shang, et al., Therapeutic Prospects of Mesenchymal Stem Cell and Their Derived Exosomes in the Regulation of the Gut Microbiota in Inflammatory Bowel Disease, Pharmaceuticals (Basel, Switzerland) 17 (2024) 607.

[10] Y. Mo, A. Shang, G. Wei, D. Xu, Y. Hou, X. Shao, et al., Juvenile idiopathic arthritis and primary ovarian failure: a two-sample Mendelian randomization analysis in a mixed-gender cohort, Front. Endocrinol. (Lausanne) 15 (2024) 1340993.

[11] C. Zhao, A. Shang, H. Wu, Q. Li, L. Peng, C. Yue, Causal relationship between genetically predicted uterine leiomyoma and cancer risk: a two-sample Mendelian randomization, Front. Endocrinol. (Lausanne) 15 (2024) 1429165.

[12] W. Chang, J. Zhu, D. Yang, A. Shang, Z. Sun, W. Quan, et al., Plasma versican and plasma exosomal versican as potential diagnostic markers for non-small cell lung cancer, Respir. Res. 24 (2023) 140.

[13] Y. Ping, J. Huang, J. Zhu, Z. Sun, A. Shang, C. Chen, et al., Comprehensive analyses of molecular features, prognostic values, and regulatory functionalities of m(6)A-modified long non-coding RNAs in lung adenocarcinoma, Clin. Epigenetics 15 (2023) 60.

[14] C. Shu, W. Wang, L. Wu, C. Qi, W. Yan, W. Lu, et al., LINC00936/microRNA-221-3p Regulates Tumor Progression in Ovarian Cancer by Interacting with LAMA3, Recent Pat. Anticancer Drug Discov. 18 (2023) 66-79.

[15] C. Gu, A. Shang, G. Liu, J. Zhu, W. Zhang, L. Jin, et al., Identification of CD147-positive extracellular vesicles as novel non-invasive biomarkers for the diagnosis and prognosis of colorectal cancer, Clin. Chim. Acta 548 (2023) 117510.

[16] Z. Li, Z. Duan, K. Jia, Y. Yao, K. Liu, Y. Qiao, et al., A Combined Risk Score Model to Assess Prognostic Value in Patients with Soft Tissue Sarcomas, Cells 11 (2022) 4077.

[17] L. Shen, W. Zhang, Y. Yuan, W. Zhu, A. Shang, Vaginal microecological characteristics of women in different physiological and pathological period, Front Cell Infect Microbiol 12 (2022) 959793.

[18] L. Shen, W. Wang, W. Hou, C. Jiang, Y. Yuan, L. Hu, et al., The function and mechanism of action of uterine microecology in pregnancy immunity and its complications, Front Cell Infect Microbiol 12 (2022) 1025714.

[19] F. Han, W. Wang, M. Shi, H. Zhou, Y. Yao, C. Li, et al., Outer membrane vesicles from bacteria: Role and potential value in the pathogenesis of chronic respiratory diseases, Front Cell Infect Microbiol 12 (2022) 1093327.

[20] S. Song, H. Tang, W. Quan, A. Shang, C. Ling, Estradiol initiates the immune escape of non-small cell lung cancer cells via ERβ/SIRT1/FOXO3a/PD-L1 axis, Int. Immunopharmacol. 107 (2022) 108629.

[21] S. Zhao, A. Shang, M. Guo, L. Shen, Y. Han, X. Huang, The advances in the regulation of immune microenvironment by Candida albicans and macrophage cross-talk, Front. Microbiol. 13 (2022) 1029966.

[22] H. Wang, J. Hu, J. Wu, P. Ji, A. Shang, D. Li, The Function and Molecular Mechanism of Commensal Microbiome in Promoting Malignant Progression of Lung Cancer, Cancers (Basel) 14 (2022) 5394.

[23] G. Liu, J. Wu, G. Chen, A. Shang, The potential therapeutic value and application prospect of engineered exosomes in human diseases, Front Cell Dev Biol 10 (2022) 1051380.

[24] C. Chen, A. Shang, Y. Gao, J. Huang, G. Liu, W.C. Cho, et al., PTBPs: An immunomodulatory-related prognostic biomarker in pan-cancer, Front Mol Biosci 9 (2022) 968458.

[25] C. Chen, A. Shang, Z. Sun, Y. Gao, J. Huang, Y. Ping, et al., Urinary Exosomal Long Noncoding RNA TERC as a Noninvasive Diagnostic and Prognostic Biomarker for Bladder Urothelial Carcinoma, J Immunol Res 2022 (2022) 9038808.

[26] Y. Gao, H. Zhou, G. Liu, J. Wu, Y. Yuan, A. Shang, Tumor Microenvironment: Lactic Acid Promotes Tumor Development, J Immunol Res 2022 (2022) 3119375.

[27] C. Gu, J. Wu, W. Zhang, Y. Yao, W. Yan, Y. Yuan, et al., Immune Infiltration of Ulcerative Colitis and Detection of the m6A Subtype, J Immunol Res 2022 (2022) 7280977.

[28] J. Tian, W. Wang, J. Zhu, Y. Zhuang, C. Qi, Z. Cai, et al., Histone Methyltransferase SETDB1 Promotes Immune Evasion in Colorectal Cancer via FOSB-Mediated Downregulation of MicroRNA-22 through BATF3/PD-L1 Pathway, J Immunol Res 2022 (2022) 4012920.

[29] W. Zhang, W. Wang, W. Hou, C. Jiang, J. Hu, L. Sun, et al., The diagnostic utility of IL-10, IL-17, and PCT in patients with sepsis infection, Front Public Health 10 (2022) 923457.

[30] Z. Li, H. Huang, X. Wu, T. Yu, F. Xiao, H. Zhou, et al., SRSF3 Expression Serves as a Potential Biomarker for Prognostic and Immune Response in Pan-Cancer, Front. Oncol. 12 (2022) 808530.

[31] W. Zhang, W. Wang, J. Wu, J. Tian, W. Yan, Y. Yuan, et al., Immune cell-lipoprotein imbalance as a marker for early diagnosis of non-small cell lung cancer metastasis, Front. Oncol. 12 (2022) 942964.

[32] L. Wu, W. Wang, J. Tian, C. Qi, Z. Cai, W. Yan, et al., Intravenous Delivery of RNA Encoding Anti-PD-1 Human Monoclonal Antibody for Treating Intestinal Cancer, J. Cancer 13 (2022) 579-588.

[33] D. Qiao, C. Gu, W. Wang, W. Yan, C. Jiang, J. Hu, et al., Tumor-Originated Exosomal hsa-miR-3937 as a Minimally Invasive Early Biomarker for Liquid Biopsy of Colorectal Cancer, J. Oncol. 2022 (2022) 6990955.

[34] W. Yan, W. Liu, J. Wu, L. Wu, S. Xuan, W. Wang, et al., Neuropeptide Y in the amygdala contributes to neuropathic pain-like behaviors in rats via the neuropeptide Y receptor type 2/mitogen-activated protein kinase axis, Bioengineered 13 (2022) 8101-8114.

[35] C. Gu, W. Chang, J. Wu, Y. Yao, G. Liu, Y. Yuan, et al., NCOA4: An Immunomodulation-Related Prognostic Biomarker in Colon Adenocarcinoma and Pan-Cancer, J. Oncol. 2022 (2022) 5242437.

[36] T. Deng, A. Shang, Y. Zheng, L. Zhang, H. Sun, W. Wang, Log (Lactobacillus crispatus/ Gardnerella vaginalis): a new indicator of diagnosing bacterial vaginosis, Bioengineered 13 (2022) 2981-2991.

[37] C. Gu, C. Li, W. Wang, W. Yan, Y. Yao, M. Shi, et al., Immune Infiltration and N(6)-Methyladenosine ncRNA Isoform Detection in Acute Lung Injury, J. Oncol. 2022 (2022) 3922299.

[38] J. Wu, G. Chen, W. Wang, Y. Yang, Y. Yuan, A. Shang, et al., GTPBP4: A New Therapeutic Target Gene Promotes Tumor Progression in Non-Small Cell Lung Cancer via EMT, J. Oncol. 2022 (2022) 2164897.

[39] W. Wang, L. Wu, J. Tian, W. Yan, C. Qi, W. Liu, et al., Cervical Cancer Cells-Derived Extracellular Vesicles Containing microRNA-146a-5p Affect Actin Dynamics to Promote Cervical Cancer Metastasis by Activating the Hippo-YAP Signaling Pathway via WWC2, J. Oncol. 2022 (2022) 4499876.

[40] G.H. Zhai, W. Zhang, Z. Xiang, L.Z. He, W.W. Wang, J. Wu, et al., Diagnostic Value of sIL-2R, TNF-α and PCT for Sepsis Infection in Patients With Closed Abdominal Injury Complicated With Severe Multiple Abdominal Injuries, Front. Immunol. 12 (2021) 741268.

[41] J. Cui, J. Tian, W. Wang, T. He, X. Li, C. Gu, et al., IGF2BP2 promotes the progression of colorectal cancer through a YAP-dependent mechanism, Cancer Sci. 112 (2021) 4087-4099.

[42] Z. Sun, S. Ji, J. Wu, J. Tian, W. Quan, A. Shang, et al., Proteomics-Based Identification of Candidate Exosomal Glycoprotein Biomarkers and Their Value for Diagnosing Colorectal Cancer, Front. Oncol. 11 (2021) 725211.

[43] F. Wang, J. Tian, L. Pang, J. Wu, A. Shang, Z. Sun, et al., Retinoic Acid-Induced Gene G(RIG-G) as a Novel Monitoring Biomarker in Leukemia and Its Clinical Applications, Genes (Basel) 12 (2021) 1035.

[44] W.W. Wang, L. Wu, W. Lu, W. Chen, W. Yan, C. Qi, et al., Lipopolysaccharides increase the risk of colorectal cancer recurrence and metastasis due to the induction of neutrophil extracellular traps after curative resection, J. Cancer Res. Clin. Oncol. 147 (2021) 2609-2619.

[45] Y. Yu, W. Wang, W. Lu, W. Chen, A. Shang, Inhibin β-A (INHBA) induces epithelial-mesenchymal transition and accelerates the motility of breast cancer cells by activating the TGF-β signaling pathway, Bioengineered 12 (2021) 4681-4696.

[46] L. Wu, W. Wang, J. Tian, C. Qi, Z. Cai, W. Yan, et al., Engineered mRNA-expressed bispecific antibody prevent intestinal cancer via lipid nanoparticle delivery, Bioengineered 12 (2021) 12383-12393.

[47] A. Shang, C. Gu, W. Wang, X. Wang, J. Sun, B. Zeng, et al., Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p- TGF-β1 axis, Mol. Cancer 19 (2020) 117.

[48] A. Shang, C. Gu, C. Zhou, Y. Yang, C. Chen, B. Zeng, et al., Exosomal KRAS mutation promotes the formation of tumor-associated neutrophil extracellular traps and causes deterioration of colorectal cancer by inducing IL-8 expression, Cell Communication and Signaling 18 (2020) 52.

[49] J. Cui, A. Shang, W. Wang, W. Chen, Rational design of a GLP-1/GIP/Gcg receptor triagonist to correct hyperglycemia, obesity and diabetic nephropathy in rodent animals, Life Sci. 260 (2020) 118339.

[50] J. Ma, L. Zhang, A. Shang, H. Song, J. Huo, M. Zhang, et al., LINC02163 promotes colorectal cancer progression via miR-511-3p/AKT3 axis, Artif Cells Nanomed Biotechnol 48 (2020) 961-968.

[51] H. Pan, Y. Su, Y. Xie, W. Wang, W. Qiu, W. Chen, et al., Everestmab, a novel long-acting GLP-1/anti GLP-1R nanobody fusion protein, exerts potent anti-diabetic effects, Artif Cells Nanomed Biotechnol 48 (2020) 854-866.

[52] J. Sun, X. Wang, W. Liu, P. Ji, A. Shang, J. Wu, et al., Novel evidence for retinoic acid-induced G (Rig-G) as a tumor suppressor by activating p53 signaling pathway in lung cancer, FASEB J. 34 (2020) 11900-11912.

[53] W. Liu, D. Yang, L. Chen, Q. Liu, W. Wang, Z. Yang, et al., Plasma Exosomal miRNA-139-3p is a Novel Biomarker of Colorectal Cancer, J. Cancer 11 (2020) 4899-4906.

[54] J. Qi, W. Wang, W. Lu, W. Chen, H. Sun, A. Shang, Design and biological evaluation of novel BF-30 analogs for the treatment of malignant melanoma, J. Cancer 11 (2020) 7184-7195.

[55] B. Zeng, P. Ji, C. Chen, J. Sun, C. Gu, A. Shang, et al., A nomogram from the SEER database for predicting the prognosis of patients with non-small cell lung cancer, Int. J. Biochem. Cell Biol. 127 (2020) 105825.

[56] J. Wu, X. Wang, A. Shang, G. Vella, Z. Sun, P. Ji, et al., PLAC8 inhibits oral squamous cell carcinogenesis and epithelial-mesenchymal transition via the Wnt/β-catenin and PI3K/Akt/GSK3β signaling pathways, Oncol. Lett. 20 (2020) 128.

[57] A. Shang, W. Wang, C. Gu, C. Chen, B. Zeng, Y. Yang, et al., Long non-coding RNA HOTTIP enhances IL-6 expression to potentiate immune escape of ovarian cancer cells by upregulating the expression of PD-L1 in neutrophils, JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 38 (2019) 411.

[58] H. Pan, Y. Xie, W. Lu, Y. Chen, Z. Lu, J. Zhen, et al., Engineering an enhanced thrombin-based GLP-1 analog with long-lasting glucose-lowering and efficient weight reduction, RSC Advances 9 (2019) 30707-30714.

[59] G.P. Liu, W.W. Wang, W.Y. Lu, A.Q. Shang, The mechanism of miR-16-5p protection on LPS-induced A549 cell injury by targeting CXCR3, Artif Cells Nanomed Biotechnol 47 (2019) 1200-1206.

[60] P.J. Chen, A.Q. Shang, J.P. Yang, W.W. Wang, microRNA-874 inhibition targeting STAT3 protects the heart from ischemia-reperfusion injury by attenuating cardiomyocyte apoptosis in a mouse model, J. Cell Physiol. 234 (2019) 6182-6193.

[61] A.Q. Shang, W.W. Wang, Y.B. Yang, C.Z. Gu, P. Ji, C. Chen, et al., Knockdown of long noncoding RNA PVT1 suppresses cell proliferation and invasion of colorectal cancer via upregulation of microRNA-214-3p, Am. J. Physiol. Gastrointest. Liver Physiol. 317 (2019) G222-G232.

[62] A. Shang, C. Zhou, G. Bian, W. Chen, W. Lu, W. Wang, et al., miR-381-3p restrains cervical cancer progression by downregulating FGF7, J. Cell Biochem. 120 (2019) 778-789.

[63] J. Qi, W.W. Wang, W. Chen, W.Y. Lu, A.Q. Shang, Mechanism of miR-137 regulating migration and invasion of melanoma cells by targeting PIK3R3 gene, J. Cell Biochem. 120 (2019) 8393-8400.

[64] P.J. Chen, A.Q. Shang, W.W. Wang, J.P. Yang, Astragaloside suppresses tumor necrosis factor receptor-associated factor 5 signaling pathway and alleviates neurodegenerative changes in retinal pigment epithelial cells induced by isoflurane, J. Cell Biochem. 120 (2019) 1028-1037.

[65] A. Shang, W.Y. Lu, M. Yang, C. Zhou, H. Zhang, Z.X. Cai, et al., miR-9 induces cell arrest and apoptosis of oral squamous cell carcinoma via CDK 4/6 pathway, Artif Cells Nanomed Biotechnol 46 (2018) 1754-1762.

[66] L.P. Wu, J. Wu, A. Shang, M. Yang, L.L. Li, J. Yu, et al., miR-124 inhibits progression of hepatocarcinoma by targeting KLF4 and promises a novel diagnostic marker, Artif Cells Nanomed Biotechnol 46 (2018) 159-167.

[67] J. Zhao, J. Xu, A.Q. Shang, R. Zhang, A Six-LncRNA Expression Signature Associated with Prognosis of Colorectal Cancer Patients, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 50 (2018) 1882-1890.

[68] A.Q. Shang, J. Wu, F. Bi, Y.J. Zhang, L.R. Xu, L.L. Li, et al., Relationship between HER2 and JAK/STAT-SOCS3 signaling pathway and clinicopathological features and prognosis of ovarian cancer, Cancer Biol. Ther. 18 (2017) 314-322.

[69] J. Wu, Y. Tao, A. Shang, W. Wang, Y. Zhang, L. Hu, et al., Effect of the interaction between MiR-200b-3p and DNMT3A on cartilage cells of osteoarthritis patients, J. Cell. Mol. Med. 21 (2017) 2308-2316.

5、中国发明专利

[1] 一种治疗骨关节炎的组合物及负载该组合物的微针贴片， CN116617263A；

[2] 一种插管套件及插管方法，CN116328132A；

[3] 一种结直肠癌诊断标志物及其应用，CN113866413A；

[4] 基于尿液外泌体的膀胱癌标志物lncRNA TERC及其应用，CN113637753A；

[5] 肿瘤复发转移检测方法及系统，申请号202411149939.4；

[6]基于中性粒细胞极化特征的肿瘤免疫治疗疗效预测系统，CN119479772A；

[7]基于中性粒细胞极化状态的恶性肿瘤转移风险预测系统，CN120199495A。

6、中国专业著作

[1]商安全等，检验医学与临床，吉林科学技术出版社，2016.5（书/著作，第二主编）

[2]商安全等，临床医学检验指南，吉林科学技术出版社，2017.4（书/著作，第一主编）

[3]商安全等，临床分子肿瘤学，湖北科学技术出版社，2018.9（书/著作，第一主编）

[4]商安全等，临床微生物检验基础与抗感染学，2018.9（书/著作，第一主编）

[5]商安全等，炎症与肿瘤，2019. 4（书/著作，第一主编）

     7、其他：

           2019-2022连续四年获上海市医学会优秀青年科技工作者一等奖；2023年获淮海科学技术奖二等奖1项；2023年获连云港市医学新技术引进奖二等奖1项；2024年获淮海科学技术奖二等奖1项；2023年获连云港市医学新技术引进奖二等奖1项、三等奖2项等。